Researchers are responsible for applying for continuing review at least 60 days prior to study expiration. The DOH IRB reviews research under requirements in state law and federal regulation. Federal regulation allows no "grace period" or extensions to the requirement for continuing review. According to the Office of Human Research Protections updated Guidance from January 15, 2007:

"The IRB and investigators must plan ahead to meet required continuing
review dates. If an investigator has failed to provide continuing
review information to the IRB or the IRB has not reviewed and approved
a research study by the continuing review date specified by the IRB,
the research must stop, unless the IRB finds that it is in the best
interests of individual subjects to continue participating in the
research interventions or interactions. Enrollment of new subjects
cannot occur after the expiration of IRB approval. When continuing
review of a research protocol does not occur prior to the end of the
approval period specified by the IRB, IRB approval expires
automatically." See OHRP's Guidance on Continuing Review

The IRBWise electronic systems sends out reminders as a courtesy at 90, 60 and 30 days prior to expiration. However, researchers are responsible for securing continuing review.